Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response [Neuroscience]
Epilepsy, a common neurological disorder, is featured with recurrent seizures. Its underlying pathological mechanisms remain elusive. Here, we provide evidence for loss of neogenin (NEO1), a coreceptor for multiple ligands, including netrins and bone morphological proteins, in the development of epilepsy. NEO1 is reduced in hippocampi from patients with epilepsy...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Dong Sun, Zhi-Bing Tan, Xiang-Dong Sun, Zhi-Peng Liu, Wen-Bing Chen, Leena Milibari, Xiao Ren, Ling-Ling Yao, Daehoon Lee, Chen Shen, Jin-Xiu Pan, Zhi-Hui Huang, Lin Mei, Wen-Cheng Xiong Tags: Neuroscience Biological Sciences Source Type: research