Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response [Neuroscience]

Epilepsy, a common neurological disorder, is featured with recurrent seizures. Its underlying pathological mechanisms remain elusive. Here, we provide evidence for loss of neogenin (NEO1), a coreceptor for multiple ligands, including netrins and bone morphological proteins, in the development of epilepsy. NEO1 is reduced in hippocampi from patients with epilepsy...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Neuroscience Biological Sciences Source Type: research