Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing

CONCLUSIONS: The balance of adaptive immunity and protumorigenic inflammation in individual tumor microenvironments is associated with PD-1/PD-L1 resistance in urothelial cancer with the latter linked to a proinflammatory cellular state of myeloid phagocytic cells detectable in tumor and blood.PMID:33837006 | DOI:10.1158/1078-0432.CCR-20-4574

Source: Clinical Cancer Research - April 10, 2021 Category: Cancer & Oncology Authors: Li Wang John P Sfakianos Kristin G Beaumont Guray Akturk Amir Horowitz Robert P Sebra Adam M Farkas Sacha Gnjatic Austin Hake Sudeh Izadmehr Peter Wiklund William K Oh Peter M Szabo Megan Wind-Rotolo Keziban Unsal-Kacmaz Xin Yao Eric Schadt Padmanee Sharm Source Type: research