Impact of DNA repair and reactive oxygen species levels on radioresistance in pancreatic cancer

Pancreatic cancer is a devastating disease with a 5-year survival rate of less than 5% [1]. It is the 8th leading cause of cancer-related deaths; moreover, it is expected to be the second most common cause by 2030 [2,3]. So far, the only curative treatment option for pancreatic cancer is the complete surgical resection of the tumor; yet, at the time of diagnosis, only 10-20% of patients present a locally resectable disease and are eligible for surgery [4]. Around 50% of the patients present with advanced disease, including distant metastases, and in about one-third of all patients, a locally advanced, but non-metastasized disease is diagnosed [5,6].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research