Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury
Neural Plast. 2021 Mar 8;2021:6682471. doi: 10.1155/2021/6682471. eCollection 2021.ABSTRACTTraumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. In our previous randomized controlled trial, we found that a 3-month neurological music therapy intervention enhanced executive function (EF) and increased grey matter volume in the right inferior frontal gyrus (IFG) in patients with moderate-to-severe TBI (N = 40). Extending this study, we performed longitudinal rsFC analyses of resting-state fMRI data using a ROI-to-ROI approach assessing within-network and between-network rsFC in the frontoparietal (FPN), dorsal attention (DAN), default mode (DMN), and salience (SAL) networks, which all have been associated with cognitive impairment after TBI. We also performed a seed-based connectivity analysis between the right IFG and whole-brain rsFC. The results showed that neurological music therapy increased the coupling between the FPN and DAN as well as between these networks and primary sensory networks. By contrast, the DMN was less connected with sensory networks after the intervention. Similarly, there was a shift towards a less connected state within the FPN and SAL networks, which are typically hyperconnected following TBI. Improvements in EF were correlated with rsFC within the FPN and between the DMN and sensorimotor network...
Source: Neural Plasticity - Category: Neurology Authors: Noelia Mart ínez-Molina Sini-Tuuli Siponkoski Linda Kuusela Sari Laitinen Milla Holma Mirja Ahlfors P äivi Jordan-Kilkki Katja Ala-Kauhaluoma Susanna Melkas Johanna Pekkola Antoni Rodr íguez-Fornells Matti Laine Aarne Ylinen Pekka Rantanen Sanna Koskin Source Type: research
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