Emergence and impact of oprD mutations in Pseudomonas aeruginosa strains in cystic fibrosis

Cystic fibrosis (CF) is an autosomal recessive disease resulting in progressive lung damage. Pseudomonas aeruginosa lung infection in people with CF (PWCF) is common and increases with age. Established infection is associated with increased antimicrobial resistance (AMR) accompanied by intensified treatment burden, impaired quality of life and an accelerated lung function decline.[1] Some PWCF are infected with commonly shared strains. Such strains have been identified in PWCF attending Australian CF centres with AUST-02 and AUST-06 being the most prevalent in the state of Queensland.

Source: Journal of Cystic Fibrosis - March 25, 2021 Category: Respiratory Medicine Authors: Laura J. Sherrard, Bryan A. Wee, Christine Duplancic, Kay A. Ramsay, Keyur A. Dave, Emma Ballard, Claire E. Wainwright, Keith Grimwood, Hanna E. Sidjabat, David M. Whiley, Scott A. Beatson, Timothy J. Kidd, Scott C. Bell Tags: Original Article Source Type: research