Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire ‘gain-of-function’ isoDGR motifs that might play a role in atherosclerotic pathology.

Source: Atherosclerosis - March 24, 2021 Category: Cardiology Authors: Jung Eun Park, Gnanasekaran JebaMercy, Kalailingam Pazhanchamy, Xue Guo, SoFong Cam Ngan, Ken Cheng Kang Liou, Soe EinSi Lynn, Ser Sue Ng, Wei Meng, Su Chi Lim, Melvin Khee-Shing Leow, A.Mark Richards, Daniel J. Pennington, Dominique P.V. de Kleijn, Vital Source Type: research