A rare RET mutation in an Indian pedigree with familial medullary thyroid carcinoma

We report a rare RET mutation of c.2671T>G; p.Ser891Ala in Exon 15 of the RET gene in an Indian pedigree where seven family members out of 14 screened were found to be positive for the same. RET genetic analysis should be considered as an early approach in the diagnosis of medullary thyroid carcinoma (MTC) since it improves the prognosis and permits surveillance of other family members.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research