Isoform-dependent APOE secretion modulates neuroinflammation

Nature Reviews Neurology, Published online: 16 March 2021; doi:10.1038/s41582-021-00483-yApolipoprotein E (APOE) is the most abundant apolipoprotein in the brain, where it is primarily expressed and secreted by astrocytes and microglia. APOE seems to exert immunomodulatory effects in an isoform-dependent way, and a new study indicates that the APOE isoform dictates the glycosylation state and secretion of this apolipoprotein.

Source: Nature Reviews Neurology - March 16, 2021 Category: Neurology Authors: Philip Hasel Shane A. Liddelow Source Type: research