Population Pharmacokinetic Analysis of Fevipiprant in Healthy Subjects and Asthma Patients using a Tukey ’s g-and-h Distribution
Conclusion Fevipiprant PK was described by a two-compartment model with first-order absorption and first-order elimination. The TGH distribution was appropriate to describe the over-dispersed and skewed PK data as observed in the current studies. Asthma patients had approximately 37% higher exposure than healthy subjects did. Other covariates changed exposure by at most 16%. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Wang, Xinting Bartels, Christian Kulkarni, Swarupa Sangana, Ramachandra Jain, Monish Zack, Julia Yu, Jing Tags: Original Article Source Type: research