Extracellular HMGB1 promotes CD44 expression in hepatocellular carcinoma via regulating miR-21

In this study, our results indicated that extracellular HMGB1 promoted the invasion, sphere formation and EMT process of HCC by increasing CD44 expression, which was dependent on miR-21. Moreover, miR-21 upregulated CD44 expression via activating OCT4/TGF-β1 signaling. Finally, we demonstrated the activation of Rage/JNK signaling caused by extracellular HMGB1 was responsible for miR-21 overexpression. Together, these findings reveal an important role of extracellular HMGB1 in HCC progression through upregulating miR-21/CD44.PMID:33661757 | DOI:10.18632/aging.202649
Source: Aging - Category: Biomedical Science Authors: Source Type: research