Introduction: Gout and the Kidney

Hyperuricemia, gout, and the kidney are tightly intertwined. A reduced urinary fractional excretion of uric acid thus is the most common underlying mechanism in hyperuricemia and gout,1 however, as reviewed in this issue of Seminars in Nephrology, it is increasingly clear that reduced intestinal secretion resulting from ABCG2 dysfunction can lead to a “renal overload” mechanism of hyperuricemia.2 A combination of genome-wide association studies and transport physiology also has led to the identification and characterization of the major transporters involved with urate reabsorption and secretion, providing an increasingly mechanistic understa nding of uric acid homeostasis.

Source: Seminars in Nephrology - November 1, 2020 Category: Urology & Nephrology Authors: David B. Mount Source Type: research