Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: clues into the underlying mechanisms leading to disease

Mesial temporal lobe epilepsy (MTLE) is believed to be the most common type of focal epilepsy in adults [1]. In the US, the estimated prevalence is 0.51-0.66 case per 1,000 people, and the incidence is 3.1-3.4 cases per 100,000 people/year [2]. However, most information regarding the prevalence of temporal lobe epilepsies is derived from few studies, most of which have been performed in referral centres dedicated to epilepsy surgery; thus, providing skewed estimates [3]. The most striking characteristic of MTLE is the presence of a histopathological lesion, namely hippocampal sclerosis (HS), which can be detected on magnetic resonance imaging as hippocampal atrophy observed on T1-weighted images, with or without increased signal observed in T2-weighted and FLAIR images [4 –6].

Source: Seizure: European Journal of Epilepsy - March 3, 2021 Category: Neurology Authors: Estela M. Bruxel, Danielle C.F. Bruno, Amanda M. do Canto, Jaqueline C. Geraldis, Alexandre B Godoi, Mariana Martin, Iscia Lopes-Cendes Tags: Review Source Type: research