The BDNF Val < sup > 66 < /sup > Met polymorphism regulates vulnerability to chronic stress and phantom perception

In this study, we validate that the BDNF Val66Met polymorphism plays an important role in the susceptibility to the clinical manifestation of tinnitus-related distress. We demonstrate that Val/Met carriers have increased alpha power in the subgenual anterior cingulate cortex that correlates with distress levels. Furthermore, distress mediates the relationship between BDNF Val66Met polymorphism and tinnitus loudness. In other words, for Val/Met carriers, the subgenual anterior cingulate cortex sends distress-related information to the parahippocampus, which likely integrates the loudness and distress of the tinnitus percept.PMID:33637225 | DOI:10.1016/bs.pbr.2020.08.005

Source: Brain Research - February 27, 2021 Category: Neurology Authors: Sven Vanneste Anusha Mohan Dirk De Ridder Wing Ting To Source Type: research