Association between the 308 G>A variant of the TNF-α gene and risk of colorectal cancer

Publication date: Available online 27 February 2021Source: Meta GeneAuthor(s): Nastaran Bani, Mehrdad Moetamani-Ahmadi, Maryam Alidoust, Soodabeh ShahidSales, Majid Khazaei, Habibollah Esmaily, Mona Joudi-Mashhad, Gordon A. Ferns, Masoumeh Gharib, Amir Avan
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research

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Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Rita Peila, Rhonda S. Arthur, Thomas E. Rohan
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Dr David Kerr discusses four studies that caught his eye at this year's virtual ESMO meeting.Medscape Oncology
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology Commentary Source Type: news
Authors: Machado VF, Parra RS, Leite CA, Minto SB, Cunha TM, Cunha FQ, Garcia SB, Feitosa MR, da Rocha JJR, Feres O Abstract Background and purpose: The discovery of chemical substances with carcinogenic properties has allowed the development of several experimental models of colorectal cancer (CRC). Classically, experimental models of CRC in mice have been evaluated through clinical or serial euthanasia. The present study aims to investigate the role of low endoscopy in the analysis of carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Methods: Thirty C57BL6 mice were divided into two groups: a...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Publication date: Available online 8 October 2020Source: Process BiochemistryAuthor(s): Muzaffer Dükel, Zehra Tavsan, Hulya Ayar Kayali
Source: Process Biochemistry - Category: Biochemistry Source Type: research
CONCLUSION Both MICT and HIIT enhanced pre-operative functional capacity. TRIAL REGISTRATION Identifier: NCT03361150.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Regional anaesthesia Source Type: research
This study will help to evaluate the clinical feasibility, safety and effectiveness of ERAS in elderly patients undergoing colorectal resection compared with routine care. Protocol registration number: ChiCTR2000034984
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
by Mohammadreza Mohaghegh Neyshabouri, Seong-Hwan Jun, Jens Lagergren Identification of mutations of the genes that give cancer a selective advantage is an important step towards research and clinical objectives. As such, there has been a growing interest in developing methods for identification of driver genes and their temporal order within a single patient (intra -tumor) as well as across a cohort of patients (inter-tumor). In this paper, we develop a probabilistic model for tumor progression, in which the driver genes are clustered into several ordered driver pathways. We develop an efficient inference algorithm that ...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
This study aims at examining the frequency, patterns and molecular etiologies of such inter-tumoral MMR discordances. We analyzed a cohort of 2159 colorectal cancer (CRC) patients collected over a 5-year period and found that 1.3% of the patients (27/2159) had  ≥ 2 primary CRCs, and 25.9% of the patients with ≥ 2 primary CRCs (7/27) exhibited inter-tumoral MMR discordance. We then combined the seven MMR-discordant CRC patients with three additional MMR-discordant GIT carcinoma patients and evaluated their discordant patterns and associated mol ecular abnormalities. The 10 patients consiste...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
In this study we evaluated the intratumoral density of immunohistochemically stained CD8, CD20 and CD68 cells in 87 cases of CRC (48 were microsatellite stable, MSS, and 39 had microsatellite instability, MSI) in both the intratumoral tumor tissue and within the tumor-stroma interface zone (IZ) which was extracted by a previously developed unbiased hexagonal grid analytics method. Indicators of immune-cell gradients across the extracted IZ were computed and explored along with absolute cell densities, clinicopathological and molecular data, including gene mutation (BRAF, KRAS, PIK3CA) and MSI status. Multiple regression mo...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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