Implementation of the microdosimetric kinetic model using analytical microdosimetry in a treatment planning system for proton therapy

Increased biological effectiveness for hadron radiotherapy is one of the main advantages for this type of cancer treatment [1,2]. While for carbon ions and other heavy particles it is essential to consider a variable effectiveness along the beam [3], in proton therapy a single value of 1.1 is traditionally considered to quantify the relative biological effectiveness (RBE) at any depth [4]. However, multiple pre-clinical studies pointing towards variable RBE with linear energy transfer (LET) have challenged this traditional approach [5 –13].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research