Interaction of cyclosporin A molecules with alkali and transition metal atoms on Cu(111)

Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00125f. Online ahead of print.ABSTRACTThe structure of a cyclic peptide with important biological functionalities, cyclosporin A (CsA), is investigated at the single molecule level. Its adsorption on Cu(111) under ultra-high vacuum is characterised with scanning tunnelling microscopy (STM) and density functional theory. With STM investigations, we demonstrate element specific on-surface coordination schemes of CsA with coadsorbed K, Co and Fe atoms. Thus, clear insights emerge in the behaviour of cyclic peptides at interfaces and their interactions with different metal atoms, providing control of the adsorption structure and assembly and paving the way for the integration of cyclic peptides in functional metal-organic nanostructures on surfaces.PMID:33620361 | DOI:10.1039/d1cc00125f

Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Yuanyuan Guo Li Jiang Ari Paavo Seitsonen Bodong Zhang Joachim Reichert Anthoula C Papageorgiou Johannes V Barth Source Type: research