Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice

CONCLUSION: Combining task-based rehabilitative training with PTEN inhibition further promotes axon regeneration, synaptic plasticity and reorganization of the neural network, with significant improvement in forelimb skilled motor function after cervical spinal cord injury. Our study provides new therapeutic insights for spinal cord injury management in the future.PMID:33621609 | DOI:10.1016/j.bbr.2021.113197

Source: Behavioural Brain Research - February 23, 2021 Category: Neurology Authors: Lu Pan Botao Tan Weiwei Tang Meiling Luo Yuan Liu Lehua Yu Yin Ying Source Type: research