Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart

High-throughput experiments suggest that almost 20% of human proteins may be S-palmitoylatable, a post-translational modification (PTM) whereby fatty acyl chains, most commonly palmitoyl chain, are linked to cysteine thiol groups that impact on protein trafficking, distribution and function. In human, protein S-palmitoylation is mediated by a group of 23 palmitoylating ‘Asp-His-His-Cys’ domain-containing (DHHC) enzymes. There is no information on the scope of protein S-palmitoylation, or the pattern of DHHC enzyme expression, in the heart.

Source: Journal of Molecular and Cellular Cardiology - February 23, 2021 Category: Cytology Authors: Madeleine R. Miles, John Seo, Min Jiang, Zachary T. Wilson, Janay Little, Jon Hao, Joshua Andrade, Beatrix Ueberheide, Gea-Ny Tseng Source Type: research