M2 ‐Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

The designed highly biocompatible dual immune checkpoint blockade combined with photothermal therapy nanoplatform remarkably wakes up both the innate and adaptive immune responses to eliminate breast cancer –promoting tumor infiltration of cytotoxic T lymphocyte, while reversing protumor M2‐like tumor‐associated macrophages to anti‐tumor M1‐like subtype. The research may provide a promising strategy to optimize immunotherapy based on nanotechnology. AbstractImmune checkpoint inhibitor (ICI) therapy is considered to be a revolutionary anti ‐tumor strategy that may surpass other traditional therapies. Breast cancer is particularly suitable for it theoretically due to upregulation of programmed cell death 1 (PD‐1) / programmed cell death ligand 1 (PD‐L1) immune checkpoint pathway which exhausts the adaptive immune response mediate d by T lymphocytes. However, its blockades exhibit very little effect in breast cancer, owing to the lack of T lymphocytes pre‐infiltration and co‐existing of intricate immune negative microenvironment including the macrophage‐suppressed “Don't eat me” CD47 signal overexpression. Herein, a stimuli‐responsive multifunctional nanoplatform (ZIF‐PQ‐PDA‐AUN) is built. Its photothermal therapy can promote the infiltration of T lymphocytes in addition to ablating tumor cells and AUNP‐12 and PQ912 further boost both the innate and adaptive immune reactions by cutting off PD‐L1 an d CD47 signals, respectively. In contrast t...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research