Molecular characterization of invasive serogroup B Neisseria meningitidis isolates from Spain during 2015-2018: evolution of the vaccine antigen factor H binding protein (FHbp)

Neisseria meningitidis is a major cause of invasive disease worldwide, including both bacterial meningitis and septicemia, but also some other clinical presentations [1]. Serogroups A, C, W, Y and X are responsible for a high proportion of the clinical cases, but serogroup B (MenB) is still the most frequent among invasive isolates in industrialized countries [2]. While there are available polysaccharide conjugate vaccines against serogroups A, C, W and Y, either as monovalent or multivalent formulations [3], the serogroup B capsular polysaccharide is not an effective candidate as a vaccine antigen [4].
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research