ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells

Overexpression of ABC transporters is a big challenge on cancer therapy which will lead cancer cells resistance to a series of anticancer drugs. Gedatolisib is a dual PI3K and mTOR inhibitor which is under cli...

Source: Cancer Cell International - February 16, 2021 Category: Cancer & Oncology Authors: Changfu Liu, Wenge Xing, Haipeng Yu, Weihao Zhang and Tongguo Si Tags: Primary research Source Type: research