Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division

Adult hematopoietic stem cells (HSCs) are at the apex of all hematopoietic cells. Being multipotent, HSCs give rise to all blood and immune lineages. HSCs are long-lived cells and reside mostly in a quiescent state. They divide infrequently to give rise to progeny that will maintain stem cell characteristics, that is, self-renewal. They also differentiate into highly proliferative progenitors that commit to mature lineage differentiation. HSCs are endowed with high regenerative potential and can sustain the production of all mature blood and immune cells for extended periods and, for this reason, have been used for clinical transplantation for decades.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Invited Perspective Source Type: research