TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G...

Source: Journal of Neuroinflammation - February 2, 2021 Category: Neurology Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo and John H. Zhang Tags: Research Source Type: research