FUT2: filling the gap between genes and environment in Behcet's disease?

Conclusions
This study suggests for the first time a putative link between a specific gene and environment in the aetiopathogenesis of BD. The non-secretor phenotype affects mucosal glycosylation, which may explain its known association with dysbiosis and altered susceptibility to infections. A different antigenic stimulation in early life and consequent increased propensity for autoimmunity and inflammation may contribute to BD development.

Source: Annals of the Rheumatic Diseases - February 5, 2015 Category: Rheumatology Authors: Xavier, J. M., Shahram, F., Sousa, I., Davatchi, F., Matos, M., Abdollahi, B. S., Sobral, J., Nadji, A., Oliveira, M., Ghaderibarim, F., Shafiee, N. M., Oliveira, S. A. Tags: Genetics, Immunology (including allergy), Inflammation Basic and translational research Source Type: research