Host factors abolish the need for polysaccharides and extracellular matrix-binding protein in Staphylococcus epidermidis biofilm formation.

Conclusion. We suggest that the assumed importance of polysaccharides for biofilm formation is an artefact from studying biofilms in laboratory media void of human matrix components. The cell-cell aggregation of S. epidermidis can be activated by host factors without relying on either of the major adhesins, PIA and Embp, indicating a need to revisit the basic question of how S. epidermidis deploys self-produced and host-derived matrix components to form antibiotic-tolerant biofilms in vivo.
PMID: 33492206 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - January 25, 2021 Category: Microbiology Authors: Skovdal SM, Hansen LK, Ivarsen DM, Zeng G, Büttner H, Rohde H, Jørgensen NP, Meyer RL Tags: J Med Microbiol Source Type: research