Role of Oxidative Stress and Severity of Diabetic Retinopathy in Type 1 & Type 2 Diabetes

Background: Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus (DM). Oxidative stress generated on account of hyperglycemic state may lead to retinal abnormalities including DR. Objectives : To evaluate the status of antioxidant enzymes -superoxide dismutase (SOD) and catalase (CAT); with different stages of DR severity in subjects with type 1 and type 2 DM. Methods: The cross-sectional study enrolled 148 subjects with type 1 DM (n=17); type 2 DM (n=96) and non-diabetes controls (n=35). Subjects with DM were divided into two subgroups based on DR severity (mild-to-severe non-proliferative DR and proliferative DR [PDR]) and Serum glycated hemoglobin (HbA1c), lipid profile, SOD and CAT were estimated. Results: Both SOD and CAT levels were lower in diabetes subjects than non-diabetic controls. A significant positive correlation was found between HbA1C level and severity of DR (P
Source: Ophthalmic Research - Category: Opthalmology Source Type: research