Editors ’ Picks

Fiore et al. (2020) employed computational modeling, genetic manipulations, and biophysical measurements to probe the effects of tissue architecture during tumorigenesis. Basal cell carcinomas, which are driven by mediators of Shh signaling (e.g., SmoM2), bud inward and retain their basement membranes (BMs ) and rarely spread to adjacent tissues, whereas squamous cell carcinomas, which are driven by the activation of RAS/MAPK signaling (e.g., HRasG12V), initiate as folds and become invasive. SmoM2-driven buds had reduced BM stiffness, whereas the HRasG12V-driven folds had increased stiffness.

https://www.jidonline.org/article/S0022-202X(20)32361-7/fulltext?rss=yes

Source: Journal of Investigative Dermatology - January 25, 2021 Category: Dermatology Tags: Editors ’ Picks Source Type: research