Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice

We previously showed that exposure to a high-sugar and moderate-fat diet (i.e., Western diet, WD) in mice induces appreciable skin inflammation and enhances the susceptibility to imiquimod-induced psoriasiform dermatitis (PsD), suggesting that dietary components may render the skin susceptible to psoriatic inflammation. Herein, utilizing an IL-23 minicircle (MC)-based model with features of both PsD and psoriatic arthritis (PsA), we showed that intake of WD for 10 weeks predisposed mice not only to skin but also joint inflammation.

Source: Journal of Investigative Dermatology - January 21, 2021 Category: Dermatology Authors: Zhenrui Shi, Xuesong Wu, Clarissa Santos Rocha, Matthew Rolston, Emma Garcia-Melchor, Mindy Huynh, Mimi Nguyen, Timothy Law, Kelly N. Haas, Daisuke Yamada, Neal L. Millar, Yu-Jui Yvonne Wan, Satya Dandekar, Samuel T. Hwang Tags: Original Article Source Type: research