Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells

Adult hematopoiesis takes place in designated areas of the bone marrow, one of the most proliferative and metabolically active organs of the human body. The average daily output of blood cells is estimated to be in the range 4-5  × 1011 total nucleated cells (reviewed by Nombela-Arrieta and Manz) [1]. A sophisticated hierarchical arrangement relieves the rare hematopoietic stem cells (HSC) from the majority of the mitotic burden, which is carried by diverse multi-potent and lineage-restricted progenitor cells [2-8].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Perspective Source Type: research