Moffitt researchers identify how cancer cells adapt to survive harsh tumor microenvironments

(H. Lee Moffitt Cancer Center&Research Institute) To better understand the conditions that select for the Warburg Effect and the mechanisms where cells can express this metabolic adaptation, Moffitt researchers subjected nonmalignant cells to the harsh tumor microenvironment that is present during early carcinogenesis, known as ductal carcinoma in situ. In a new research article published in the Proceedings of the National Academy of Sciences, the Moffitt team shows that these conditions select for cells to express a Warburg Effect.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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1. DCISM patients had a good survival, even those with DCIS component ≥5 cm.2. Patients aged
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
CONCLUSION: In DCIS patients, the rate of second breast cancers was 7.5%. Breast conservation, involved margins after lumpectomy and shortened hormonal therapy were associated with second cancers. Patients with involved margins after lumpectomy have the highest cancer detection rate and minimal unnecessary biopsies and follow-ups. Hence, ipsilateral breast ultrasound surveillance could be personalized for this high-risk group with mammographically dense breasts.PMID:34544658 | DOI:10.1016/j.clbc.2021.08.006
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: This study established a COAGULATION-related gene signature and showed its prognostic value in IDC through a comprehensive bioinformatics analysis, which may provide a potential new prognostic mean for patients with IDC.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
CONCLUSION: FC frequently exhibits low heterogeneity, scattered microcapsules with posterior enhancement, "pit-like" or "grid-like" changes, posterior enhancement, rare hyperechoic halo, calcification, and lack of blood supply. Certain focal FC are irregularly shaped with unclear edges, with malignant signs such as crab feet and burr, hyperechoic halo, and calcification, which ultrasound BI-RADS classification may easily misdiagnose as malignant. Local magnification function should be considered, and the internal structure should be carefully observed to prevent misdiagnosis.PMID:34535389 | DOI:10.1016/j.clbc.2021.08.004
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractObjectivesTo investigate the value of an artificial intelligence (AI) system in assisting radiologists to improve the assessment accuracy of BI-RADS 0 cases in mammograms.MethodsWe included 34,654 consecutive digital mammography studies, collected between January 2011 and January 2019, among which, 1088 cases from 1010 unique patients with initial BI-RADS 0 assessment who were recalled during 2  years of follow-up were used in this study. Two mid-level radiologists retrospectively re-assessed these BI-RADS 0 cases with the assistance of an AI system developed by us previously. In addition, four entry-level rad...
Source: European Radiology - Category: Radiology Source Type: research
Turk J Med Sci. 2021 Sep 8. doi: 10.3906/sag-2103-148. Online ahead of print.ABSTRACTBACKGROUND/AIM: Paget?s disease (PD) of the breast is a very rare presentation of breast malignancy, accounting for 1?3% of all primary breast tumors. We aimed to evaluate and compare the clinicopathological featuresand clinical outcome of PD accompanied by in situ carcinoma and invasive cancer.MATERIALS AND METHODS: We used the archive of our pathology laboratory retrospectively for age, gender, history of surgery, histopathological findings, treatment modalities and follow-up information. We used the Kaplan-Meier method for survival anal...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Authors: Source Type: research
DiscussionICG administration timing during the angiography phase compared with the EPR phase improved TBR and diagnostic accuracy. Future work will focus on image pattern analysis and adaptation of the camera system to targeting fluorophores specific to breast cancer.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Pract Radiat Oncol. 2021 Aug 30:S1879-8500(21)00225-3. doi: 10.1016/j.prro.2021.08.009. Online ahead of print.ABSTRACTPURPOSE/OBJECTIVE(S): Randomized data support accelerated partial breast irradiation (APBI) for early-stage breast cancer with variable techniques and cosmesis outcomes. We have treated patients with 5-fraction prone external beam APBI for over a decade and herein report acute and late outcomes.MATERIALS/METHODS: Patients receiving APBI 600cGy x 5 between 2010-2019 were included. APBI was primarily delivered prone, with opposed tangents targeting the tumor bed expanded by 1.5cm, (cropped 6mm from skin). Ips...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
ConclusionsHigh-risk screening might facilitate downstaging of detected breast tumor among BRCA1/2 carrier population.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
The three risk assessment tools now in use fall far short. Using the latest deep learning techniques, investigators are developing more personalized ways to locate women at high risk.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.The promise of personalized medicine will eventually allow clinicians to offer individual patients more precise advice on prevention, early detection and treatment. Of course, the operative word iseventually.A closer examination of the screening tools available to detect breast c...
Source: Life as a Healthcare CIO - Category: Information Technology Source Type: blogs
More News: Academies | Cancer | Cancer & Oncology | Carcinoma | Carcinoma in Situ | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma