Cancers, Vol. 13, Pages 331: Prevalence and Predictive Factors for Upfront Dose Reduction of the First Cycle of First-Line Chemotherapy in Older Adults with Metastatic Solid Cancer: Korean Cancer Study Group (KCSG) Multicenter Study

Cancers, Vol. 13, Pages 331: Prevalence and Predictive Factors for Upfront Dose Reduction of the First Cycle of First-Line Chemotherapy in Older Adults with Metastatic Solid Cancer: Korean Cancer Study Group (KCSG) Multicenter Study Cancers doi: 10.3390/cancers13020331 Authors: In Gyu Hwang Minsuk Kwon Jin Won Kim Se Hyun Kim Yun-Gyoo Lee Jin Young Kim Su-Jin Koh Yoon Ho Ko Seong Hoon Shin Soojung Hong Tae-Yong Kim Sun Young Kim Hyun Jung Kim Hyo Jung Kim Myung Ah Lee Jung Hye Kwon Yong Sang Hong Kyung Hee Lee Sung Hwa Bae Dong-Hoe Koo Jee Hyun Kim In Sook Woo Old age alone does not reflect an intolerability to chemotherapy. However, upfront dose reduction (UDR) of the first cycle of first-line palliative chemotherapy has sometimes been chosen by physicians for older adults with metastatic cancer due to concerns regarding adverse events. The development of predictive factors for UDR of palliative chemotherapy would be helpful for treatment planning among older adults. This was a secondary analysis of a study on predicting adverse events of first-line palliative chemotherapy in 296 patients (≥70 years) with solid cancer. We assessed the prevalence of UDR of the first cycle of first-line chemotherapy and the association of UDR with the variables of geriatric assessment (GA) and chemotherapy compliance. Among the 296 patients, 177 (59.8%) patients were treated with UDR. The mean percentage of UDR for the total patient ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research