Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19.

CONCLUSIONS: The rs11385949 G>GA variant, tagging the chromosome 3 gene cluster variation and predisposing to severe COVID-19, is associated with enhanced complement activation, both with C5a and terminal complement complex, while non-O blood group with C5a levels. These findings provide a link between genetic susceptibility to more severe COVID-19 and complement activation.
PMID: 33453462 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - January 9, 2021 Category: Allergy & Immunology Authors: Valenti L, Griffini S, Lamorte G, Grovetti E, Uceda Renteria SC, Malvestiti F, Scudeller L, Bandera A, Peyvandi F, Prati D, Meroni P, Cugno M Tags: J Autoimmun Source Type: research