CCL1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-mediated Akt/PRAS40/mTOR Pathway

Tumor-associated macrophages (TAMs) promote tumor progression. The number of infiltrating TAMs is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients; however, the mechanism underlying this phenomenon is unclear. Our previous cDNA microarray analysis had revealed that the expression of C-C motif chemokine ligand 1 (CCL1) is upregulated in peripheral blood monocyte (PBMo)-derived macrophages stimulated using conditioned media from ESCC cells (TAM-like macrophages).

Source: American Journal of Pathology - January 15, 2021 Category: Pathology Authors: Masataka Fujikawa, Yu-ichiro Koma, Masayoshi Hosono, Naoki Urakawa, Kohei Tanigawa, Masaki Shimizu, Takayuki Kodama, Hiroki Sakamoto, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki Source Type: research