Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients

ConclusionA modest- to- strong correlation of ER, PR, HER-2 and Ki-67 gene expression and RS between CNBs and resection specimens was observed in the present study. The 21-gene RS test could be reliably performed on CNBs. ER, PR and HER-2 status showed remarkable concordance between the IHC and RT-PCR analyses. The concordance between paired samples was high for the IHC ER, PR and Ki-67 results and low for HER-2.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research