Re-sensitizing tumor cells to cancer drugs with epigenetic regulators.

Re-sensitizing tumor cells to cancer drugs with epigenetic regulators. Curr Cancer Drug Targets. 2021 Jan 07;: Authors: Rauscher S, Greil R, Geisberger R Abstract Cancer drug resistance is a major problem for cancer therapy. While many drugs can be effective in first line treatments, cancer cells can become resistant due to genetic (mutations and chromosomal aberrations) but also epigenetic changes. Hence, many research studies addressed epigenetic drugs in circumventing resistance to conventional therapeutics in different tumor entities and in increasing efficiency of immune checkpoint therapies. Furthermore, repositioning of already approved drugs in combination with epigenetic modifiers could potentiate their efficacy and could thus be an attractive strategy for cancer treatment. Summarizing, we recapitulate current data on epigenetic drugs and their targets in modulating sensitivity towards conventional and immune therapies, providing evidence that altering expression profiles by epigenetic modifiers holds great potential to improve clinical outcome of may cancer patients. PMID: 33423645 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research