Viruses, Vol. 13, Pages 96: Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN- γ and CLEC5A

Viruses, Vol. 13, Pages 96: Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A Viruses doi: 10.3390/v13010096 Authors: Tamiris Azamor Andréa Marques Vieira da Silva Juliana Gil Melgaço Ana Paula dos Santos Caroline Xavier-Carvalho Lucia Elena Alvarado-Arnez Leonardo Ribeiro Batista-Silva Denise Cristina de Souza Matos Camilla Bayma Sotiris Missailidis Ana Paula Dinis Ano Bom Milton Ozorio Moraes Patrícia Cristina da Costa Neves The yellow fever vaccine (YF17DD) is highly effective with a single injection conferring protection for at least 10 years. The YF17DD induces polyvalent responses, with a TH1/TH2 CD4+ profile, robust T CD8+ responses, and synthesis of interferon-gamma (IFN-γ), culminating in high titers of neutralizing antibodies. Furthermore, C-type lectin domain containing 5A (CLEC5A) has been implicated in innate outcomes in other flaviviral infections. Here, we conducted a follow-up study in volunteers immunized with YF17DD, investigating the humoral response, cellular phenotypes, gene expression, and single nucleotide polymorphisms (SNPs) of IFNG and CLEC5A, to clarify the role of these factors in early response after vaccination. Activation of CLEC5A+ monocytes occurred five days after vaccination (DAV). Following, seven DAV data showed activation of CD4+ and CD8+T cells together with early positive correlations...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research