Breast cancer radioresistance may be overcome by osteopontin gene knocking out with CRISPR/Cas9 technique.

CONCLUSION: Our results demonstrated that after knocking out the OPN gene, the MDA-MB-231 cells showed a significant radiosensitivity. Therefore, the OPN knock out in combination with conventional radiotherapy, may become an efficient therapeutic target in the future.
PMID: 33422414 [PubMed - as supplied by publisher]

Source: Cancer Radiotherapie - January 6, 2021 Category: Cancer & Oncology Authors: Behbahani RG, Danyaei A, Teimoori A, Neisi N, Tahmasbi MJ Tags: Cancer Radiother Source Type: research