Persistent expression of microRNA-125a targets is required to induce murine hematopoietic stem cell repopulating activity

Hematopoietic stem cells (HSCs) are responsible for the lifelong reconstitution of all mature blood cells. As differentiation of these cells is nonreversible and terminal, the balance between self-renewal and differentiation of HSCs is tightly regulated to ensure proper tissue function. Proper HSC function is regulated both extrinsically by environmental factors that are secreted by the supporting cells in the bone marrow known as the stem cell niche and intrinsically by stem cell intrinsic programs.

Source: Experimental Hematology - December 14, 2020 Category: Hematology Authors: Dani ëlle G. Luinenburg, Alexander Bak Dinitzen, Arthur Flohr Svendsen, R. Cengiz, Albertina Ausema, Ellen Weersing, Leonid Bystrykh, Gerald de Haan Source Type: research