Switching macrophage gene expression from inflammation-resolution to hemorrhage-resolution by redirection of activating transcription factor 1 (ATF1) binding by SMARCA4, BACH1 and histone H3K9 acetylation

Background and Aims: Atherosclerosis is inflammatory. The resolution of inflammation is an emerging area. Genome wide association studies (GWAS) have revealed a that vascular risk loci include SMARCA4, a SWI/SNF chromatin remodelling gene important for gene activation. We tested whether SMARCA4 is has a patho-mechanism relevant to atherosclerosis.

Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: Y. Ge, L. Cave, A. Seneviratne, D. Carling, J.C. Mason, D. Haskard, J.J. Boyle Source Type: research