Stimuli-Responsive Nanomaterials for Smart Tumor-Specific Phototherapeutics.

Stimuli-Responsive Nanomaterials for Smart Tumor-Specific Phototherapeutics. ChemMedChem. 2020 Dec 20;: Authors: Zhou B, Guo Z, Lin Z, Jiang BP, Shen XC Abstract Phototherapy, a type of photoresponsive regulation of biological activities, together with additional stimuli-responsive features, offers significant potential for enhancing the precision and eļ¬ƒcacy of cancer treatments. To achieve tumor-specific therapeutics, numerous studies have focused on the development of smart phototherapeutic nanomaterials (PNMs) that can respond to endogenous pathological characteristics ( e.g. , mild acidity, the overproduction of glutathione, the overproduction of hydrogen peroxide, the overexpression of specific surface receptors, etc .) present in the tumor and/or exogenous stimuli. Such responsiveness can effectively improve the physicochemical properties, cellular uptake, tumor-targeting performance, and pharmacokinetic proļ¬le of PNMs. Here, we will systematically discuss the recent advances in this field. Moreover, potential challenges and future directions in the development of stimuli-responsive PNMs are also presented to support the development of this emerging cutting-edge research area. PMID: 33345434 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research