Do Thyroid Diseases during Pregnancy and Lactation Affect the Nutritional Composition of Human Milk?

Conclusion: It is extremely important that these women have continuous nutritional follow-up to minimize the impact of these morbidities on the nutritional composition of human milk.Resumo Objetivo: Identificar se os efeitos da doen ça da tireoide durante a gestação e lactação afetam a composição nutricional do leite humano. Métodos: Revisão sistemática da literatura científica por meio das bases de dados Medical Literature Analysis and Retrieval System Online/MedLine a fim de avaliar a associação das doenças da tireoide na gestação e na lactação com a composição nutricional do leite humano. Não houve delimitação por período nem por idioma, e as buscas foram finalizadas em março de 2019. Foram aplicados os seguintes descritores: human milk AND thyroid AND composition, utilizando protocolo preferr ed reporting items for systematic reviews and meta-analyses (PRISMA) para a busca, seleção e extração de dados. De acordo com o fluxograma proposto, a busca bibliográfica resultou em 12 artigos e, destes, quatro foram selecionados. Resultados: Os artigos elegidos para a presente revisão foram publicados entre 1976 e 2018. Dois estudos verificaram diferenças significativas na composição nutricional do leite de mães com hipotireoidismo ou excess...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research

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AbstractSubclinical Hypothyroidism (SCH) is defined as a raised level of serum TSH level in the presence of normal circulating free thyroid hormones. SCH is a highly prevalent condition displaying some peculiarities, both in terms of the diagnostic and therapeutic approach, when specific population and/or concomitant diseases are taken into account. The debate upon whether LT4 therapy should be initiated or not in patients with SCH is a long lasting one and still it remains controversial. Current evidence supports the concept that the clinical consequences of SCH may be profoundly different in relation to several patient-s...
Source: Endocrine - Category: Endocrinology Source Type: research
Purpose of review Subclinical hypothyroidism (SCH) is a common diagnosis among women of reproductive age. The importance of sufficient maternal thyroid supply during pregnancy is well known. Nevertheless, the effects of SCH during pregnancy and the efficacy of its treatment on maternofetal outcomes are not well established. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Recent findings Recent observational studies have found a positive association between SCH during pregnancy and adverse maternal, neonatal and offspring outcomes, mainly in thy...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: THYROID: Edited by Angela M. Leung Source Type: research
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
CONCLUSIONS: Clinical assessment of young female patient including that of obtaining full medical history with a focus on the perceived changes in appearance, psychological symptoms and menstrual irregularities supported by laboratory tests indicative of metabolic status and characteristic changes in thyroid functions, may be the key to well-reasoned and justified individual therapeutic decisions. PMID: 31002146 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Jie Cai1†, Yi Zhang1†, Yuying Wang1, Shengxian Li1, Lihua Wang1, Jun Zheng1, Yihong Jiang1, Ying Dong1, Huan Zhou1, Yaomin Hu1, Jing Ma1, Wei Liu1,2*† and Tao Tao1*† 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China 2Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China Background: Infertility and dyslipidemia are frequently present in both women...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionMaternal hypothyroidism in pregnancy is independently associated with long-term pediatric neurological morbidity of the offspring.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Abstract Context/Objective: Targeted screening with high-risk case finding is proposed for the detection of thyroid dysfunction in pregnant women rather than universal screening (US). To determine the detection rate of subclinical and overt hypothyroidism (SCH/OH) based on American Thyroid Association guidelines (ATA-GL) criteria, and if it could be improved? Design, Setting, Participants: Cross-sectional study in 1832 pregnant women in a single centre. Thyroid function (TSH and free T4) and iron status was determined. The high-risk group (HRG) included women with ≥1 ATA-GL risk factor and the low-risk gro...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
ernal-Fetal Medicine Units Network (MFMU) Abstract OBJECTIVE: To study the association of prepregnancy body mass index (BMI) and gestational weight gain with child neurodevelopmental outcomes. METHODS: We performed a secondary analysis of data from two parallel, multicenter, randomized, double-blind, placebo-controlled thyroxine replacement trials in pregnant women with either hypothyroxinemia or subclinical hypothyroidism who delivered at term. Body mass index was categorized as normal (18.5-24.9), overweight (25.0-29.9), or obese (30 or greater). We also evaluated early (20 weeks of gestation or less), late...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Sara Ornaghi, Paola Algeri, Lyudmyla Todyrenchuk, Emanuela Vertemati, Patrizia VerganiAbstractObjectivesTo investigate the effects of excessive pre-pregnancy body mass index (BMI) and abnormal gestational weight gain on adverse outcomes in women with chronic hypertension (CH).Study designA retrospective cohort study of CH women with singleton pregnancy delivered at our Institution in 2002–2013. Women were categorized as normal, overweight, and obese, according to their pre-pregnancy BMI. Further stratification was based on gestational wei...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Authors: Hepp Z, Lage MJ, Espaillat R, Gossain VV Abstract OBJECTIVE: To evaluate outcomes associated with adherence to levothyroxine (LT4) in the US adult hypothyroidism population. METHODS: We used data from Truven's MarketScan databases from July 1, 2011 through December 31, 2015. Patients aged 18 or older were diagnosed with hypothyroidism (confirmed at least twice) and prescribed LT4. Patients were excluded if they did not have continuous insurance coverage or if they received a diagnosis of thyroid cancer or pregnancy during the study period. Multivariable analyses on a matched cohort of adherent and non-...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
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