Comprehensive genomic profiling of Brazilian non ‐small cell lung cancer patients (GBOT 0118/LACOG0418)

In conclusion, this retrospective analysis of genomic data from NSCLC patients obtained by CGP showed that common abnormalities such asEGFR mutations andALK rearrangements had similar frequency to those previously described by other groups using others strategies. Additionally, our data confirm an association betweenTP53 p.R337H, supposedly germline in nature, and somatic mutations in genes of the HER family.Key pointsSignificant findings of the study This is the first report of the prevalence of driver mutations in Brazilian NSCLC patients using comprehensive genomic profiling (CGP). The frequency of the most common driver mutations in this population was similar to that previously described in Brazil.What this study addsTP53 was the most commonly comutated gene across samples.TP53 p.R337H was associated with somatic mutations inEGFR andERBB2. Most samples had low TMB; only 5.5% of samples had high TMB.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research