Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells

The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy —the gain and/or loss of chromosomes—whi...

Source: Molecular Brain - December 14, 2020 Category: Neuroscience Authors: Whitney S. McDonald, Kyoko Miyamoto, Richard Rivera, Grace Kennedy, Beatriz S. V. Almeida, Marcy A. Kingsbury and Jerold Chun Tags: Research Source Type: research