Intravenous Acetaminophen in Postoperative Patients —Reply

In Reply Dr Shankar asserts that 1 g of acetaminophen (paracetamol) given every 6 hours would not reach steady-state plasma concentrations until late in our 48-hour treatment period. In fact, pharmacokinetic studies indicate that 1 g of intravenous acetaminophen given every 6 hours provides steady plasma concentrations. But more importantly, therapeutic concentrations are reached within 1 hour of the initial dose, and no further effect is seen with an increasing dose.
Source: JAMA - Category: General Medicine Source Type: research