The effect of propolis supplementation on clinical symptoms in patients with coronavirus (COVID-19): A structured summary of a study protocol for a randomised controlled trial

This study aims to assess the effect of propolis supplementation on clinical symptoms in patients with coronavirus (COVID-19).Trial designThis is a Double-Blind, Placebo-Controlled, Parallel Arm, Randomized Phase ΙΙ Clinical Trial.ParticipantsPatients with the confirmed COVID-19 based on the PCR test are eligible to participate in the trial if they are 18 to 75 years of age and have no history of the current use of warfarin or propolis supplement and presence of sensitivity to bee products. Patients will be recruited from the Al-Zahra hospital in Isfahan city, Isfahan, Iran.Intervention and comparatorParticipants (N=40) in the intervention group will receive an identical propolis tablet (containing 300  mg Iranian green propolis extract) three times a day for a period of 2 weeks. Participants (N=40) in the control group will receive an identical placebo tablet (containing 300 mg microcrystalline cellulose) three times a day for 2 weeks. All tablets are prepared by the Reyhan Naghsh Jahan Pharmac eutical Co., Isfahan, Iran.Main outcomesThe main outcomes are changes in the coronavirus disease ’s clinical symptoms including duration and severity from baseline to the end of 2 weeks.RandomizationEligible patients will be randomly allocated in a 1:1 ratio to the intervention or control group. Randomization will be performed on the basis of permuted block sizes of 4 and will be stratified according to sex categories. Randomization sequences will be prepared by the trial ’s p...
Source: Trials - Category: Research Source Type: clinical trials