The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor (VDR) in vivo.

Conclusion Taken together, these data indicate a fundamental regulatory role of the VDR in the regulation of myogenesis and muscle mass; whereby it acts to maintain muscle mitochondrial function and limit autophagy. Joseph Bass completed his PhD in Medicine and Health in 2017 at The University of Nottingham, where he is currently a Research Fellow. Joe is interested in examining the mechanistic regulation of musculoskeletal health, particularly factors impacting muscle atrophy susceptibility. This article is protected by copyright. All rights reserved. PMID: 33258480 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33258480?dopt=Abstract

Source: The Journal of Physiology - December 1, 2020 Category: Physiology Authors: Bass JJ, Kazi AA, Deane CS, Nakhuda A, Ashcroft SP, Brook MS, Wilkinson DJ, Phillips BE, Philp A, Tarum J, Kadi F, Andersen D, Garcia AM, Smith K, Gallagher IJ, Szewczyk NJ, Cleasby ME, Atherton PJ Tags: J Physiol Source Type: research