New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics.
New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics.
Biochem Soc Trans. 2020 Dec 01;:
Authors: Krstevski C, Cohen CD, Dona MSI, Pinto AR
Abstract
Single-cell transcriptomics enables inference of context-dependent phenotypes of individual cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading factor in the development of heart failure and a major cause of morbidity and mortality worldwide with no effective treatment. Single-cell RNA-sequencing (scRNA-seq) offers a promising new platform to identify new cellular and molecular protagonists that may drive cardiac fibrosis and development of heart failure. This review will summarize the application scRNA-seq for understanding cardiac fibrosis and development of heart failure. We will also discuss some key considerations in interpreting scRNA-seq data and some of its limitations.
PMID: 33259583 [PubMed - as supplied by publisher]
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Krstevski C, Cohen CD, Dona MSI, Pinto AR Tags: Biochem Soc Trans Source Type: research