Aberrant basal ganglia-thalamo-cortical network topology in juvenile absence epilepsy: A resting-state EEG-fMRI study

Juvenile absence epilepsy (JAE) is characterized as frequent absence seizures onset in adolescence, often triggered by photic stimulation or hyperventilation [1]. Electroencephalography (EEG) typically shows generalized spike-wave discharges (GSWDs) at three times per second. JAE is a syndrome of genetic generalized epilepsy, also called idiopathic generalized epilepsy. Patients with JAE are thought to have high probability of generalized tonic-clonic seizures (GTCS) occurrence [1]. Antiepileptic drugs are usually effective, but remission rates after drug withdrawal are relatively low [2,3].

Source: Seizure: European Journal of Epilepsy - November 30, 2020 Category: Neurology Authors: Tianyu Zhang, Yingying Zhang, Jiechuan Ren, Cheng Yang, Huanyu Zhou, Lei Li, Du Lei, Qiyong Gong, Dong Zhou, Tianhua Yang Source Type: research