Diagnosis of Preclinical Crohn ’s Disease: Hurdles, Challenges, and Hopes

We read with interest the paper by Taylor et  al.1 The authors calculated a risk score for asymptomatic first-degree relatives (FDR) of patients with Crohn's disease (CD) by combining the genetic risk score (a synthesis of 72 CD variants) and smoking status. Such score was used to identify FDRs in the lowest and highest quartiles of CD risk. FDRs were then invited to undergo video capsule endoscopy (VCE). They then built a model to predict inflammation at VCE that included several variables. Variable selection and regularization were carried out using different methods.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research