Synergistic effect of PAF inhibition and X-ray irradiation in non-small cell lung cancer cells

ConclusionThese data demonstrate that reduced expression of PAF enhances radiosensitivity in NSCLC cells. Mechanistically, inhibition of the MEK/ERK and Wnt/ β-catenin signaling pathways caused by PAF interference may lead to impaired cell function and enhance sensitivity to X‑rays. Targeting PAF may therefore serve as a potential therapeutic strategy to increase the efficiency of radiotherapy in NSCLC patients, ultimately improving patient survival.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research